Cognomen Mphephanduku (Mphephanduku 
) , in all the world, is a very rare family name. The cognomen Mphephanduku is habitual in Sub-Saharan Africa, particularly South Africa, where it is a very rare surname.
| VARIANT | COUNTRY |
|---|---|
| Mphephanduku | South Africa |
Kwalunga, Nosipho, and Sithandazile